XBP1 Antibody - CD BioSciences

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XBP1 Antibody

XBP1 Antibody

SPA-11837

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0.05 mg Online Inquiry
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Target Information
Target Name XBP1
Gene Abbr. XBP1
Gene ID 7494
Full Name X-box binding protein 1
Alias TREB-5, TREB5, XBP-1, XBP2
Introduction X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen A 17 aa synthetic peptide near the C-terminus of human XBP1. The immunogen is located within the last 50 aa of XBP1.
Usage
Application WB, ELISA, IF, IHC
Dilutions Western Blot (1-2 µg/mL); Immunofluorescence (1:10-1:500); Immunohistochemistry (5 µg/mL)
Reactivity Human, Mouse, Rat
Specificity 17 amino acid peptide from near the carboxy terminus of human XBP-1. This antibody will only recognize the non-spliced (shorter) isoform.
Storage & Handling
Storage Buffer PBS.
Preservative 0.02% Sodium Azide
Storage Temp. Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.