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Cell Signaling Pathway Reporter Screening
Signaling pathways regulate cellular processes, such as apoptosis, inflammation, metabolism and angiogenesis. Dysregulations of signaling-transduction pathways lead to malfunction of those processes and result in pathological or disease states.
To have a better understanding of the regulation of signaling pathways and find potential drugs or treatments for diseases, CD BioSciences offers well-established cell-based reporter assays to evaluate the impact of therapeutics or gene manipulations in signaling pathways.
Screening Options
- Personalized Screening
- Quantitative Measurements
- Profiling across Multiple Signaling Pathways
With access to a growing menu of reporters for monitoring cell signaling events, we screen chemical compounds, RNAi libraries or CRISPR sgRNA libraries against the signaling pathway reporters upon your requests.
With a 10-point dose-response curve performed in duplicate, we will determine agonist half maximal effective concentrations (EC50) and antagonist half maximal inhibitory concentrations (IC50) upon your request.
With a comprehensive signaling pathway reporter assay service portfolio, we provide quick profiling of compounds or gene modifications across multiple signaling pathways to gain insight into mechanisms of their response to compound treatment or gene manipulation.
List of Signaling Pathway Reporters
CD BioSciences has developed a large set of signaling pathway reporters for monitoring the cellular signaling events involved in cell growth, metabolism, ER stress, immune response, etc.
| Reporter | Pathway/Application |
| AP1 | SAPK/JNK Signaling Pathway |
| ARE | Nrf2 Antioxidant Pathway |
| CREB/CRE | cAMP/PKA Signaling Pathway |
| FOXO | PI3K/AKT Signaling Pathway |
| GAS | IFNγ Signaling Pathway; JAK/STAT1 Signaling Pathway |
| Gli | Hedgehog Signaling Pathway |
| GR-GAL4 | Glucocorticoid Signaling Pathway |
| ISRE | JAK/STAT Signaling Pathway; IFNα Signaling Pathway |
| Myc | Myc Signaling Pathway |
| NF-κB | NF-κB Signaling Pathway; RANKL/RANK Signaling Pathway |
| NFAT | PKC/ Ca2+ Signaling Pathway; Immune Checkpoint |
| Notch1/CSL | Notch Signaling Pathway |
| PAI-1 | TGF-β Signaling Pathway |
| RARα | RARα-regulated Pathway |
| RARβ | RARβ-regulated Pathway |
| RARγ | RARγ-regulated Pathway |
| SBE | TGF/SMAD Signaling Pathway |
| SRE | MAPK/ERK Signaling Pathway |
| STAT3 | STAT3 Signaling Pathway |
| STAT5 | STAT5 Signaling Pathway |
| TCF/LEF | Wnt/β-catenin Signaling Pathway |
| TEAD | Hippo Signaling Pathway |
| TrkA/SRE | NGF/TrkA Signaling Pathway |
| XBP1 | ER Stress & UPR |
Advantages of Our Signaling Pathway Reporter Assays
- Versatile Applications
- Drugs Targeting Multiple Signaling Pathways
- Comprehensive Understanding
Our cell lines are not only suitable for screening chemical compounds, but also can be used to build assays specific for RNAi or CRISPR screening to identify novel regulators of the signaling pathways.
Our service provides a chance to develop drugs targeting multiple signaling pathways simultaneously.
Evaluating both receptor-proximal and receptor-distal responses for a comprehensive understanding of the drug molecule's mechanism of action.
Features
CD BioSciences offers cost-effect, high quality and hassle-free cell signaling pathway reporter screening services to our clients worldwide. We guarantee to deliver our results on time. Please feel free to contact us.
For research use only. Not intended for any clinical use.