Tuberin/TSC2 siRNA I - CD BioSciences

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Tuberin/TSC2 siRNA I

Tuberin/TSC2 siRNA I

SPR-01126

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Target Information
Target Name TSC2
Gene Abbr. TSC2
Gene ID 7249
Full Name TSC complex subunit 2
Alias LAM, PPP1R160, TSC4
Introduction Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development. Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. Tuberin is directly phosphorylated at Thr1462 by Akt/PKB. Phosphorylation at Thr1462 and Tyr1571 regulates tuberin-hamartin complexes and tuberin activity. In addition, tuberin inhibits the mammalian target of rapamycin (mTOR), which promotes inhibition of p70 S6 kinase, activation of eukaryotic initiation factor 4E binding protein 1 (4E-BP1, an inhibitor of translation initiation), and eventual inhibition of translation.p38-activated kinase MK2 (MAPKAPK-2) phosphorylates Ser1254 of tuberin, and thus augments the interaction between tuberin and 14-3-3.
Usage
Application RNA interference
Reactivity
Storage & Handling
Storage Buffer The siRNA product is supplied in RNAse-free water.
Storage Temp. Aliquot and store at -20 °C.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.