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Total BACE Sandwich ELISA Kit
SPK-00083
| Size | Price |
| 1 X 96T | Online Inquiry |
| 5 X 96T | Online Inquiry |
| 10 X 96T | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | BACE |
| Gene Abbr. | BACE1 |
| Gene ID | 23621 |
| Full Name | beta-secretase 1 |
| Alias | ASP2, BACE, HSPC104 |
| Introduction | β-secretase (BACE) is an aspartic acid proteinase that catalyses the initial step in APP processing by cleaving and releasing a soluble, extracellular APP-β (sAPPβ) ectodomain and generating a membrane-bound, carboxy-terminal fragment consisting of 99 amino acids (CTF99). Additional processing of CTF99 by γ-secretase generates the amyloid β-peptide (Aβ) that forms aggregates in the brains of Alzheimer disease (AD) patients. BACE is an attractive target for inhibitors in AD therapy since it catalyses the first and rate limiting step in amyloidogenic APP processing. Pro-BACE-1 is synthesized in the ER before it is transported to the trans-Golgi network to undergo maturation. BACE-1 functions as a dimer and is phosphorylated at Ser498 by casein kinase 1, which is necessary for recycling back to the membrane from the early endosome. |
| Product Details | |
|---|---|
| Measurement | Sandwich |
| Usage | |
|---|---|
| Application | ELISA |
| Reactivity | |
| Sensitivity | This kit detects endogenous and transfected levels of BACE protein. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.