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TIE1 Antibody
SPA-10746
| Size | Price |
| 25 µg | Online Inquiry |
| 500 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Tie-1 |
| Gene Abbr. | TIE1 |
| Gene ID | 7075 |
| Full Name | tyrosine kinase with immunoglobulin like and EGF like domains 1 |
| Alias | JTK14, TIE |
| Introduction | TIE1 belongs to the Tie family of receptor tyrosine kinases. TIE1 is structurally similar to its homolog TIE2, but differs from the latter in that it does not have a known ligand and is thus considered an orphan receptor. A key function of TIE1 is to modulate TIE2 signaling, via heterodimerization with TIE2 at the cell surface. The effects of TIE1-TIE2 interaction are context-dependent; heterodimerization can either promote or inhibit downstream TIE2 signaling depending on localized TIE2 levels. Research studies have shown TIE1 to be implicated in angiogenesis, vascular maturation, tissue remodeling, and inflammation. Increased expression of TIE1 has also been associated with cancer stemness and atherosclerosis formation. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 8D12B10 |
| Isotype | IgG1 |
| Immunogen | Purified recombinant fragment of human TIE1 (AA: 385-607) expressed in E. coli. |
| Usage | |
|---|---|
| Application | WB, ELISA, IHC |
| Dilutions | Western Blot (1:500-1:2000); ELISA (1:10000); Immunohistochemistry (1:200-1:1000) |
| Reactivity | Human |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS. |
| Preservative | 0.05% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.