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STING/TMEM173 Antibody
SPA-10410
| Size | Price |
| 0.025 mg | Online Inquiry |
| 0.1 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | STING |
| Gene Abbr. | STING1 |
| Gene ID | 340061 |
| Full Name | stimulator of interferon response cGAMP interactor 1 |
| Alias | ERIS, MITA, MPYS, NET23, SAVI |
| Introduction | STING (stimulator of interferon genes) is encoded by the TMEM173 gene and is an adaptor molecule involved in the activation of innate immune responses to PAMPS (pathogen-associated molecular patterns) and DAMPS (damage-associated molecular patterns). STING specifically recognizes cytosolic DNA products derived from pathogens (e.g., cytomegalovirus, vaccinia virus, Listeria monocytogenes) or dead cells. In the STING pathway, dsDNA derived from pathogens or damaged cells serves as a substrate for the enzyme cGAS (cyclic GMP-AMP synthase) which produces the second messenger cyclic GMP-AMP (cGAMP) from ATP and GTP. Under steady-state conditions STING (theoretical molecular weight 42 kDa), a protein localizes to the ER membrane. Upon activation by dsDNA derived second messenger (cGAMP), STING translocates to the Golgi apparatus as a homodimer. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | OTI4H1 |
| Isotype | IgG2A |
| Immunogen | This STING/TMEM173 Antibody (OTI4H1) was developed against full length human recombinant protein of human STING/TMEM173 (NP_938023) produced in HEK293T cell. |
| Usage | |
|---|---|
| Application | WB, IHC |
| Dilutions | Western Blot (1:2000); Immunohistochemistry (1:100) |
| Reactivity | Human |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS (pH 7.3), 1.0% BSA and 50% Glycerol. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.