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Sorbitol Dehydrogenase Antibody
SPA-10235
| Size | Price |
| 0.1 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Sorbitol Dehydrogenase |
| Gene Abbr. | SORD |
| Gene ID | 6652 |
| Full Name | sorbitol dehydrogenase |
| Alias | HEL-S-95n, RDH, SDH, SORD1, SORDD |
| Introduction | Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme. Sorbitol dehydrogenase catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications. The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor. It has been noted that the polyol pathway is particularly active in hyperglycemic states. Although SORD is closely related to the class I long-chain alcohol dehydrogenases, it differs in substrate specificity, catalyzing polyols such as sorbitol and xylitol but having no activity towards primary alcohols. |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Peptide with sequence KIMLKCDPSDQNP corresponding to C-Terminus according to NP_003095.2. |
| Usage | |
|---|---|
| Application | WB, ELISA |
| Dilutions | Western Blot (0.1-0.3 µg/mL); ELISA (1:16000) |
| Reactivity | Human, Mouse, Rat, Canine |
| Storage & Handling | |
|---|---|
| Storage Buffer | Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Avoid freeze-thaw cycles. |
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