Online Inquiry
S1P1/EDG-1 Antibody
SPA-09809
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | S1P1/EDG-1 |
| Gene Abbr. | S1PR1 |
| Gene ID | 1901 |
| Full Name | sphingosine-1-phosphate receptor 1 |
| Alias | CD363, CHEDG1, D1S3362, ECGF1, EDG-1 |
| Introduction | S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins. S1P1 signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. It plays an important role in cell migration via its role in the reorganization of the actin cytoskeleton and formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. S1P1 is required for normal chemotaxis toward sphingosine 1-phosphate, normal embryonic heart development, and normal cardiac morphogenesis. |
| Product Details | |
|---|---|
| Host | Rat |
| Clonality | Monoclonal |
| Clone No. | 713412 |
| Isotype | IgG2A |
| Immunogen | Mouse S1P1/EDG‑1 synthetic peptide (T4-H28). O08530. |
| Usage | |
|---|---|
| Application | FC, IHC |
| Dilutions | Flow Cytometry (0.25 µg/10^6 cells); Immunohistochemistry (8-25 µg/mL) |
| Reactivity | Mouse |
| Specificity | Detects mouse S1P1/EDG‑1 peptide in direct ELISAs. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.