Ron Antibody - CD BioSciences

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Ron Antibody

Ron Antibody

SPA-09713

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100 µL Online Inquiry
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Target Information
Target Name Ron
Gene Abbr. MST1R
Gene ID 4486
Full Name macrophage stimulating 1 receptor
Alias CD136, CDw136, NPCA3, PTK8, RON
Introduction Ron is a member of the Met protooncogene family of receptor tyrosine kinases, which also includes Stk, c-Met, and c-Sea. The functional Ron is a heterodimer composed of a 40 kDa α chain and a 150 kDa β chain. Ron is initially synthesized in the cells as a single-chain, pro-Ron precursor that is cleaved into the two active chains. The α chain is completely extracellular, whereas the β chain traverses the cell membrane and contains the intracellular tyrosine kinase and regulatory elements. Ron mediates multiple signaling cascades that involve cell motility, adhesion, proliferation, and apoptosis. The signaling pathways activated downstream of Ron include the ras/mitogen-activated protein kinase (MAPK), phosphatidyl inositol-3 kinase (PI3K)/Akt, and focal adhesion kinase (FAK) pathways. Ron activation can also significantly increase c-Src activity, a signaling intermediate involved in cell cycle progression, motility, angiogenesis and survival. The function of Ron has been shown to be important for embryological development as well as implicated in the progression and metastasis of tumors.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. 1B5
Immunogen Recombinant Trx-Ron fusion protein containing amino acids 210-320 of human Ron expressed in E. coli.
Source/Purification Antibody is produced by immunizing animals with a recombinant Trx-Ron fusion protein containing amino acids 210-320 of human Ron expressed in E. coli.
Usage
Application WB
Dilutions Western Blot (1:1000)
MW(KDa) 145-150
Reactivity Human
Sensitivity Endogenous
Specificity This antibody detects endogenous levels of the 170 kDa full-length Ron protein. This antibody does not cross-react with other family members.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide.
Preservative Less than 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.