Recombinant Rat Eukaryotic translation initiation factor 4E-binding protein 1 (Eif4ebp1) - CD BioSciences

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Recombinant Rat Eukaryotic translation initiation factor 4E-binding protein 1 (Eif4ebp1)

Recombinant Rat Eukaryotic translation initiation factor 4E-binding protein 1 (Eif4ebp1)

SPP-00053

Size Price
20 μg Online Inquiry
100 μg Online Inquiry
500 μg Online Inquiry
Target Information
Species Rattus norvegicus
Target Name 4EBP
UniProt No. Q62622
Tissue Specificity Expressed in all tissues examined; highest levels in fat and skeletal tissue, lowest levels in kidney.
Gene Abbr. Eif4ebp1
Full Name eukaryotic translation initiation factor 4E binding protein 1
Alias PHAS-I
Introduction Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity. Multiple 4E-BP1 residues are phosphorylated in vivo. While phosphorylation by FRAP/mTOR at Thr37 and Thr46 does not prevent the binding of 4E-BP1 to eIF4E, it is thought to prime 4E-BP1 for subsequent phosphorylation at Ser65 and Thr70.
Product Details
Product Type Recombinant Protein
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.