Recombinant Human 14-3-3 protein beta/alpha (YWHAB) - CD BioSciences


Recombinant Human 14-3-3 protein beta/alpha (YWHAB)

Recombinant Human 14-3-3 protein beta/alpha (YWHAB)


Size Price
1 mg Online Inquiry
100 μg Online Inquiry
20 μg Online Inquiry
Target Information
Species Homo sapiens
Target Name 14-3-3
UniProt No. P31946
Subcellular Location Cytoplasm, Melanosome
Gene Abbr. YWHAB
Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Alias GW128, HEL-S-1, HS1, KCIP-1, YWHAA
Introduction The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, β, γ, ε, σ, ζ, τ, and η that have been identified in mammals. The initially described α and δ isoforms are confirmed to be phosphorylated forms of β and ζ, respectively. Through their amino-terminal α helical region, 14-3-3 proteins form homo- or heterodimers that interact with a wide variety of proteins: transcription factors, metabolic enzymes, cytoskeletal proteins, kinases, phosphatases, and other signaling molecules. The interaction of 14-3-3 proteins with their targets is primarily through a phospho-Ser/Thr motif. However, binding to divergent phospho-Ser/Thr motifs, as well as phosphorylation independent interactions has been observed. 14-3-3 binding masks specific sequences of the target protein, and therefore, modulates target protein localization, phosphorylation state, stability, and molecular interactions. 14-3-3 proteins may also induce target protein conformational changes that modify target protein function. Distinct temporal and spatial expression patterns of 14-3-3 isoforms have been observed in development and in acute response to extracellular signals and drugs, suggesting that 14-3-3 isoforms may perform different functions despite their sequence similarities. Several studies suggest that 14-3-3 isoforms are differentially regulated in cancer and neurological syndromes.
Product Details
Product Type Recombinant Protein
Buffer before Lyophilization If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Note: If you have any special requirement for the glycerol content, please remark when you place the order.
Storage & Handling
Storage Temp. Store at -20 °C upon receipt unless otherwise instructed.
Handling Aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

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