Presenilin 2 Antibody - CD BioSciences

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Presenilin 2 Antibody

Presenilin 2 Antibody

SPA-09244

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Target Information
Target Name Presenilin 2
Gene Abbr. PSEN1
Gene ID 5663
Full Name presenilin 1
Alias ACNINV3, AD3, FAD, PS-1, PS1
Introduction Nicastrin is a transmembrane glycoprotein serving as an essential component of the γ-secretase complex. Nicastrin is physically associated with presenilin and plays an important role in the stabilization and correct localization of presenilin to the membrane-bound γ-secretase complex. Nicastrin also serves as a docking site for γ-secretase substrates such as APP and Notch, directly binding to them and properly presenting them to γ-secretase to ensure the correct cleavage process.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. D30G3
Immunogen Synthetic peptide corresponding to residues surrounding Met323 of human Presenilin 2 protein.
Source/Purification Antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Met323 of human Presenilin 2 protein.
Usage
Application WB, IP
Dilutions Western Blot (1:1000); Immunoprecipitation (1:50)
MW(KDa) 23 (C-terminal), 54 (full-length)
Reactivity Human, Mouse, Rat
Sensitivity Endogenous
Specificity It recognizes endogenous levels of total Presenilin 2 protein.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide.
Preservative Less than 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.