Presenilin 2 Antibody - CD BioSciences

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Presenilin 2 Antibody

Presenilin 2 Antibody

SPA-09243

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Target Information
Target Name Presenilin 2
Gene Abbr. PSEN1
Gene ID 5663
Full Name presenilin 1
Alias ACNINV3, AD3, FAD, PS-1, PS1
Introduction Nicastrin is a transmembrane glycoprotein serving as an essential component of the γ-secretase complex. Nicastrin is physically associated with presenilin and plays an important role in the stabilization and correct localization of presenilin to the membrane-bound γ-secretase complex. Nicastrin also serves as a docking site for γ-secretase substrates such as APP and Notch, directly binding to them and properly presenting them to γ-secretase to ensure the correct cleavage process.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Immunogen Synthetic peptide corresponding to residues surrounding amino acid 330 of human presenilin 2.
Source/Purification Antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding amino acid 330 of human presenilin 2. Antibodies are purified by protein A and peptide affinity chromatography.
Usage
Application WB, IP
Dilutions Western Blot (1:1000); Immunoprecipitation (1:50)
MW(KDa) 23 (C-terminal), 54 (full-length)
Reactivity Human, Mouse, Rat, Monkey
Sensitivity Endogenous
Specificity It detects endogenous levels of the carboxy-terminal fragment of presenilin 2 (23 kDa) and the full length protein (54 kDa) to a lesser extent. It does not cross-react with endogenous levels of presenilin 1.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol.
Preservative No Preservative
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.