Pref-1/DLK1/FA1 Antibody - CD BioSciences

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Pref-1/DLK1/FA1 Antibody

Pref-1/DLK1/FA1 Antibody

SPA-02934

Size Price
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100 µg Online Inquiry
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Target Information
Target Name DLK1
Gene Abbr. DLK1
Gene ID 8788
Full Name delta like non-canonical Notch ligand 1
Alias DLK, DLK-1, Delta1, FA1, PREF1
Introduction This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq]
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. 1168B
Isotype IgG
Immunogen Mouse myeloma cell line NS0-derived recombinant mouse Pref-1/DLK1/FA1. Ala24-Gln305. Accession # Q09163.
Usage
Application WB, FC, IHC
Dilutions Western Blot (0.1 µg/mL); Flow Cytometry (0.25 µg/10^6 cells); Immunohistochemistry (1-25 µg/mL)
Reactivity Mouse
Specificity Detects mouse Pref-1 in direct ELISAs.
Storage & Handling
Storage Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative Sodium Azide
Storage Temp. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Handling Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

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