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POMC Antibody
SPA-09181
| Size | Price |
| 0.1 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | POMC |
| Gene Abbr. | POMC |
| Gene ID | 5443 |
| Full Name | proopiomelanocortin |
| Alias | ACTH, CLIP, LPH, MSH, NPP |
| Introduction | This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Peptide with sequence C-NAIIKNAYKKGE corresponding to C-Terminus according to NP_000930.1, NP_001030333.1. |
| Usage | |
|---|---|
| Application | WB, FC, IF, IHC, ELISA |
| Dilutions | Western Blot (0.3-2 µg/mL); Flow Cytometry (10 µg/mL); Immunohistochemistry (2-4 µg/mL); ELISA (1:128000) |
| Reactivity | Human, Mouse, Rat, Porcine, Sheep |
| Specificity | Both transcript variants encode the same protein. In Western Blot, this product appears to react with the full length precursor protein only. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.