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Phospho-MKK6/MEK6 (Ser207) Antibody
SPA-07632
| Size | Price |
| 0.05 mL | Online Inquiry |
| 0.025 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | MKK6 |
| Gene Abbr. | MAP2K6 |
| Gene ID | 5608 |
| Full Name | mitogen-activated protein kinase kinase 6 |
| Alias | MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3 |
| Introduction | MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase. MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAPK/JNK. Phosphorylation of p38 MAP kinase dramatically stimulates its ability to phosphorylate protein substrates such as ATF-2 and Elk-1. MKK3 and MKK6 are both activated by different forms of cellular stress and inflammatory cytokines. Activation of MKK3 and MKK6 occurs through phosphorylation at Ser189 and Thr222 on MKK3 and Ser207 and Thr211 on MKK6. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Synthesized phosphopeptide derived from human MKK6 around the phosphorylation site of serine 207 (V-D-SP-V-A). |
| Usage | |
|---|---|
| Application | WB, IF, IHC |
| Dilutions | Western Blot (1:500-1:1000); Immunofluorescence (1:100-1:200); Immunohistochemistry (1:50-1:100) |
| MW(KDa) | 38 |
| Reactivity | Human, Mouse, Rat |
| Specificity | It detects endogenous levels of MKK6 only when phosphorylated at serine207. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS (without Mg2+, Ca2+) (pH 7.4), 150 mM NaCl, 50% Glycerol. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.