Phospho-IRE1α (Ser551) Antibody - CD BioSciences

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Phospho-IRE1α (Ser551) Antibody

Phospho-IRE1α (Ser551) Antibody

SPA-06550

Size Price
100 µL Online Inquiry
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Target Information
Target Name IRE1α
Gene Abbr. ERN1
Gene ID 2081
Full Name endoplasmic reticulum to nucleus signaling 1
Alias IRE1, IRE1P, IRE1a, hIRE1p
Introduction The secretory, intra-organellar and transmembrane proteins translocate into the endoplasmic reticulum (ER) after their synthesis. Inside the ER, they are post-translationally modified and properly folded. Disruptions of ER homeostasis leads to the accumulation of unfolded proteins. The ER has developed an adaptive mechanism called unfolded protein response (UPR) to counteract compromised protein folding. One of the players in UPR, IRE1, was first identified in Saccharomyces cerevisiae as a transmembrane serine/threonine kinase. This kinase was proposed to be a proximal sensor for UPR that transmits the unfolded protein signal across the ER membrane. A human homolog of this kinase, IRE1α, was later identified and shown to be ubiquitously expressed in human tissues. Upon activation of UPR, IRE1α splices X-box binding protein (XBP1) mRNA by an unconventional mechanism using its endoribonuclease activity. This converts XBP1 into a potent transcriptional activator that induces many UPR responsive genes. Recently, IRE1α was shown to mediate the rapid degradation of certain mRNAs based on the ER-localization and primary sequences of their encoded proteins, suggesting a novel mechanism in UPR.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen A phospho specific peptide corresponding to residues surrounding Ser551 of human IRE1 alpha.
Usage
Application WB
Dilutions Western Blot (1:500-1:2000)
MW(KDa) 130
Reactivity Human
Storage & Handling
Storage Buffer PBS with 50% glycerol, pH 7.3.
Preservative 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Avoid freeze-thaw cycles.

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