Phospho-FAK (Tyr397) Antibody - CD BioSciences

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Phospho-FAK (Tyr397) Antibody

Phospho-FAK (Tyr397) Antibody

SPA-03777

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100 µg Online Inquiry
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Target Information
Target Name FAK
Gene Abbr. PTK2
Gene ID 5747
Full Name protein tyrosine kinase 2
Alias FADK, FAK, FAK1, FRNK, PPP1R71
Introduction Focal adhesion kinase (FAK) is a widely expressed cytoplasmic protein tyrosine kinase involved in integrin-mediated signal transduction. It plays an important role in the control of several biological processes, including cell spreading, migration, and survival. Activation of FAK by integrin clustering leads to autophosphorylation at Tyr397, which is a binding site for the Src family kinases PI3K and PLCγ. Recruitment of Src family kinases results in the phosphorylation of Tyr407, Tyr576, and Tyr577 in the catalytic domain, and Tyr871 and Tyr925 in the carboxy-terminal region of FAK.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Immunogen Synthetic phosphopeptide corresponding to residues surrounding Tyr397 of human FAK.
Source/Purification Antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr397 of human FAK. Antibodies are purified by protein A and peptide affinity chromatography.
Usage
Application WB
Dilutions Western Blot (1:1000)
MW(KDa) 125
Reactivity Human, Mouse, Rat, Hamster, Pig
Sensitivity Endogenous
Specificity It detects endogenous levels of FAK only when phosphorylated at Tyr397. This antibody may cross-reacts with other tyrosine-phosphorylated RTKs.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol.
Preservative No Preservative
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.