Phospho-CXCR4 (Ser339) Antibody - CD BioSciences

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Phospho-CXCR4 (Ser339) Antibody

Phospho-CXCR4 (Ser339) Antibody

SPA-02577

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Target Information
Target Name CXCR4
Gene Abbr. CXCR4
Gene ID 7852
Full Name C-X-C motif chemokine receptor 4
Alias CD184, D2S201E, FB22, HM89, HSY3RR
Introduction CXCR4 is a chemokine receptor that belongs to the G protein-coupled receptor family. It is activated by a small cytokine, CXCL12, also known as stromal cell derived factor 1 (SDF-1). The main function of CXCR4 is the mediation of the homing of progenitor cells in the bone marrow and their recruitment to sites of injury. More recently, CXCR4 has been studied, as a potential therapeutic target, in the context of autoimmune diseases as well as cancer, as the receptor is involved in the regulation of migration, proliferation, and survival of cancer cells.CXCR4 is phosphorylated at Ser339 by G protein-coupled receptor kinase 6 upon treatment of cells with CXCL12. Phosphorylation of CXCR4 at Ser339 has also been observed following epidermal growth factor and phorbol ester treatment. TCR-mediated transactivation of CXCR4 at Ser339 activates a PREX1-Rac1-signaling pathway that stabilizes interleukin-2, -4, and -10 messenger RNA transcripts.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Immunogen Synthetic phosphopeptide corresponding to residues surrounding Ser339 of human CXCR4 protein.
Source/Purification Antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser339 of human CXCR4 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Usage
Application WB
Dilutions Western Blot (1:1000)
MW(KDa) 45-60
Reactivity Human
Sensitivity Endogenous
Specificity It recognizes endogenous levels of CXCR4 protein only when phosphorylated at Ser339. This antibody does not cross-react with CXCR4 protein when phosphorylated at Ser324 or Ser325.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol.
Preservative No Preservative
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.