Phospho-Cofilin (Ser3) Antibody - CD BioSciences

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Phospho-Cofilin (Ser3) Antibody

Phospho-Cofilin (Ser3) Antibody

SPA-02286

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Target Information
Target Name Cofilin
Gene Abbr. CFL1
Gene ID 1072
Full Name cofilin 1
Alias CFL, HEL-S-15, cofilin
Introduction Cofilin and actin-depolymerization factor (ADF) are members of a family of essential conserved small actin-binding proteins that play pivotal roles in cytokinesis, endocytosis, embryonic development, stress response, and tissue regeneration. In response to stimuli, cofilin promotes the regeneration of actin filaments by severing preexisting filaments. The severing activity of cofilin is inhibited by LIMK or TESK phosphorylation at Ser3 of cofilin. Phosphorylation at Ser3 also regulates cofilin translocation from the nucleus to the cytoplasm.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. 77G2
Immunogen Synthetic phosphopeptide corresponding to residues surrounding Ser3 of human cofilin.
Source/Purification Antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser3 of human cofilin.
Usage
Application WB, IF
Dilutions Western Blot (1:1000)
MW(KDa) 19
Reactivity Human, Mouse, Rat, Monkey, Bovine
Sensitivity Endogenous
Specificity It detects endogenous levels of cofilin only when phosphorylated at serine 3.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide.
Preservative Less than 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.