Phospho-CaMKK2 (Ser511) Antibody - CD BioSciences

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Phospho-CaMKK2 (Ser511) Antibody

Phospho-CaMKK2 (Ser511) Antibody

SPA-01329

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Target Information
Target Name CaMKK2
Gene Abbr. CAMKK2
Gene ID 10645
Full Name calcium/calmodulin dependent protein kinase kinase 2
Alias CAMKK, CAMKKB
Introduction Calcium/Calmodulin-dependent Protein Kinase Kinase 2 (CaMKK2) is a member of the CaMK family that contains a central Ser/Thr kinase domain followed by a regulatory domain consisting of overlapping autoinhibitory and CaM-binding regions. CaMKK2 can be distinguished from other CaMK family members by the presence of a unique Pro/Arg/Gly-rich insert following the ATP-binding domain. CaMKK2 phosphorylates CaMKI at Thr177 and CaMKIV at Thr200. CaMKK2 also phosphorylates AMPKα in response to calcium. CaMKK2 has been implicated in long-term memory formation and adipocyte development. CaMKK2 is phosphorylated at Ser511 by death-associated protein kinase (DAPK) in a signaling cascade thought to be involved in neuronal death.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Immunogen Synthetic phosphopeptide corresponding to residues surrounding Ser511 of human CaMKK2 protein.
Source/Purification Antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser511 of human CaMKK2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Usage
Application WB
Dilutions Western Blot (1:1000)
MW(KDa) 68
Reactivity Human, Mouse, Rat
Sensitivity Endogenous
Specificity It recognizes endogenous levels of CaMKK2 protein only when phosphorylated at Ser511.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol.
Preservative No Preservative
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.