Phospho-c-Kit (panTyr) Sandwich ELISA Antibody Pair - CD BioSciences

service-banner

Phospho-c-Kit (panTyr) Sandwich ELISA Antibody Pair

Phospho-c-Kit (panTyr) Sandwich ELISA Antibody Pair

SPK-00154

Size Price
1 X 96T Online Inquiry
5 X 96T Online Inquiry
10 X 96T Online Inquiry
More Options Online Inquiry
Target Information
Target Name CD117/c-kit
Gene Abbr. KIT
Gene ID 3815
Full Name KIT proto-oncogene, receptor tyrosine kinase
Alias C-Kit, CD117, MASTC, PBT, SCFR
Introduction c-Kit is a member of the subfamily of receptor tyrosine kinases that includes PDGF, CSF-1, and FLT3/flk-2 receptors. It plays a critical role in activation and growth in a number of cell types including hematopoietic stem cells, mast cells, melanocytes, and germ cells. Upon binding with its stem cell factor (SCF) ligand, c-Kit undergoes dimerization/oligomerization and autophosphorylation. Activation of c-Kit results in the recruitment and tyrosine phosphorylation of downstream SH2-containing signaling components including PLCγ, the p85 subunit of PI3 kinase, SHP2, and CrkL. Molecular lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders and mutations that constitutively activate c-Kit can lead to pathogenesis of mastocytosis and gastrointestinal stromal tumors. Tyr719 is located in the kinase insert region of the catalytic domain. c-Kit phosphorylated at Tyr719 binds to the p85 subunit of PI3 kinase in vitro and in vivo.
Product Details
Measurement Sandwich
Usage
Application ELISA
Reactivity
Sensitivity For Antibody Pair specificity and sensitivity, please refer to the corresponding Sandwich ELISA Kit.
Storage & Handling
Storage Temp. Capture and detection antibodies are stored at 4°C. HRP-linked secondary reagent is stored at -20°C.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.