Phospho-c-Jun (Ser63) Antibody - CD BioSciences

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Phospho-c-Jun (Ser63) Antibody

Phospho-c-Jun (Ser63) Antibody

SPA-01228

Size Price
25 µg Online Inquiry
100 µg Online Inquiry
More Options Online Inquiry
Target Information
Target Name c-Jun
Gene Abbr. JUN
Gene ID 3725
Full Name Jun proto-oncogene, AP-1 transcription factor subunit
Alias AP-1, AP1, c-Jun, cJUN, p39
Introduction c-Jun is a member of the Jun family containing c-Jun, JunB, and JunD, and is a component of the transcription factor activator protein-1 (AP-1). AP-1 is composed of dimers of Fos, Jun, and ATF family members and binds to and activates transcription at TRE/AP-1 elements. Extracellular signals including growth factors, chemokines, and stress activate AP-1-dependent transcription. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 through SAPK/JNK. Knock-out studies in mice have shown that c-Jun is essential for embryogenesis and subsequent studies have demonstrated roles for c-Jun in various tissues and developmental processes including axon regeneration liver regeneration and T cell development. AP-1 regulated genes exert diverse biological functions including cell proliferation, differentiation, and apoptosis, as well as transformation, invasion and metastasis, depending on cell type and context. Other target genes regulate survival, as well as hypoxia and angiogenesis. Research studies have implicated c-Jun as a promising therapeutic target for cancer, vascular remodeling, acute inflammation, and rheumatoid arthritis.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. 1018Y
Isotype IgG
Immunogen Phosphopeptide containing the human c-Jun S63 site. P05412.
Usage
Application WB, IF
Dilutions Western Blot (0.5 µg/mL); Immunofluorescence (1-25 µg/mL)
MW(KDa) 48
Reactivity Human
Specificity Detects human c-Jun when phosphorylated at S63 in Western Blots.
Storage & Handling
Storage Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative Sodium Azide
Storage Temp. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Handling Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

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