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Phospho-Axl (Tyr702) Antibody
SPA-00814
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Axl |
| Gene Abbr. | AXL |
| Gene ID | 558 |
| Full Name | AXL receptor tyrosine kinase |
| Alias | ARK, JTK11, Tyro7, UFO |
| Introduction | Axl, Mer and Tyro3 are three members of the TAM family receptor tyrosine kinase that share a common NCAM (neural adhesion molecule)-related extracellular domain and a conserved intracellular tyrosine kinase domain. These receptors bind common homologous vitamin K dependent protein GAS6 and protein S to activate downstream signaling pathways. TAM family receptors are involved in the development of immune, nervous, vascular and reproductive systems, autoimmune disease, cancer drug resistance and tumor immunity response. Axl (Tyr698), Axl (Tyr702), Mer Tyr(749) and Tyro3 (Tyr681) are conserved autophosphorylation sites located in the activation loop of the respective tyrosine kinase domains. Phosphorylation at these sites is required for full kinase activation of each of the corresponding receptors. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | D12B2 |
| Immunogen | Detailed sequence is available upon request. |
| Usage | |
|---|---|
| Specificity | Each antibody in the YAP/TAZ Transcriptional Targets Antibody Sampler Kit detects endogenous levels of its target protein. Pan-TEAD Rabbit mAb was shown to react with TEAD1, 2, 3 and 4 using gene-specific transfected cell extracts. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.