Phospho-ATM (Ser1981) Antibody - CD BioSciences

service-banner

Phospho-ATM (Ser1981) Antibody

Phospho-ATM (Ser1981) Antibody

SPA-00740

Size Price
0.025 mg Online Inquiry
0.1 mg Online Inquiry
More Options Online Inquiry
Target Information
Target Name ATM
Gene Abbr. ATM
Gene ID 472
Full Name ATM serine/threonine kinase
Alias AT1, ATA, ATC, ATD, ATDC
Introduction Ataxia telangiectasia mutated kinase (ATM) is a serine/threonine kinase that regulates cell cycle checkpoints and DNA repair. Activation of ATM by autophosphorylation on Ser1981 occurs in response to exposed DNA double stranded breaks. ATM kinase regulates a number of proteins involved in cell cycle checkpoint control, apoptosis, and DNA repair. Known substrates include p53, Chk2, Chk1, CtIP, 4E-BP1, BRCA1, RPA3, H2A.X, SMC1, FANCD2, Rad17, Artemis, Nbs1, and the I-2 regulatory subunit of PP1. Mutations in the corresponding ATM gene result in ataxia telangiectasia an autosomal recessive disease characterized by uncoordinated muscle movement and neurodegeneration. Cells from AT patients display defective DNA damage-induced checkpoint activation, sensitivity to radiation, and a higher frequency of chromosome breakage.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. D6H9
Immunogen Synthetic peptide corresponding to residues surrounding Ser1981 of human ATM protein.
Source/Purification Antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser1981 of human ATM protein.
Usage
Application WB
Dilutions Western Blot (1:1000)
MW(KDa) 350
Reactivity Human
Sensitivity Endogenous
Specificity It recognizes endogenous levels of ATM protein only when phosphorylated at Ser1981.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide.
Preservative Less than 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.