Phospho-ATF-2 (Ser112/Ser94) Antibody - CD BioSciences


Phospho-ATF-2 (Ser112/Ser94) Antibody

Phospho-ATF-2 (Ser112/Ser94) Antibody


Size Price
0.025 mg Online Inquiry
0.05 mg Online Inquiry
More Options Online Inquiry
Target Information
Target Name ATF-2
Gene Abbr. ATF2
Gene ID 1386
Full Name activating transcription factor 2
Alias CRE-BP1, CREB-2, CREB2, HB16, TREB7
Introduction The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF-2 interacts with a variety of viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines, and UV irradiation, stimulate the transcriptional activity of ATF-2. Cellular stress activates ATF-2 by phosphorylation of Thr69 and Thr71. Both SAPK and p38 MAPK have been shown to phosphorylate ATF-2 at these sites in vitro and in cells transfected with ATF-2. Mutations of these sites result in the loss of stress-induced transcription by ATF-2. In addition, mutations at these sites reduce the ability of E1A and Rb to stimulate gene expression via ATF-2.ATF-7 is another member of the ATF/CREB family of leucine zipper proteins. Similarly, Thr51 and Thr53 (corresponding to Thr69 and Thr71 of ATF-2, respectively) can be phosphorylated under different conditions.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen A peptide sequence around aa.110~114 or 92~96 (D-L-S-P-L) derived from Human ATF2.
Application WB, IHC
Dilutions Western Blot (1:500-1:1000); Immunohistochemistry (1:50-1:100)
MW(KDa) 65, 75
Reactivity Human, Mouse, Rat
Specificity This antibody detects endogenous level of total ATF2 protein.
Storage & Handling
Storage Buffer PBS (without Mg2+, Ca2+) (pH 7.4), 150 mM NaCl, 50% Glycerol.
Preservative 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Avoid freeze/thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.