Phospho-ALK (Tyr1604) Chemiluminescent Sandwich ELISA Kit - CD BioSciences

service-banner

Phospho-ALK (Tyr1604) Chemiluminescent Sandwich ELISA Kit

Phospho-ALK (Tyr1604) Chemiluminescent Sandwich ELISA Kit

SPK-00056

Size Price
1 X 96T Online Inquiry
5 X 96T Online Inquiry
10 X 96T Online Inquiry
More Options Online Inquiry
Target Information
Target Name ALK
Gene Abbr. ALK
Gene ID 238
Full Name ALK receptor tyrosine kinase
Alias CD246, NBLST3
Introduction Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor for pleiotrophin (PTN), a growth factor involved in embryonic brain development. In ALK-expressing cells, PTN induces phosphorylation of both ALK and the downstream effectors IRS-1, Shc, PLCγ, and PI3 kinase. ALK was originally discovered as a nucleophosmin (NPM)-ALK fusion protein produced by a translocation. Investigators have found that the NPM-ALK fusion protein is a constitutively active, oncogenic tyrosine kinase associated with anaplastic lymphoma. Research literature suggests that activation of PLCγ by NPM-ALK may be a crucial step for its mitogenic activity and involved in the pathogenesis of anaplastic lymphomas.A distinct ALK oncogenic fusion protein involving ALK and echinoderm microtubule-associated protein like 4 (EML4) has been described in the research literature from a non-small cell lung cancer (NSCLC) cell line, with corresponding fusion transcripts present in some cases of lung adenocarcinoma. The short, amino-terminal region of the microtubule-associated protein EML4 is fused to the kinase domain of ALK.
Product Details
Measurement Sandwich
Usage
Application ELISA
Reactivity
Sensitivity This kit detects endogenous levels of phospho-ALK (Tyr1604) protein, phospho-EML4-ALK and phospho-NPM-ALK fusion proteins in human cells.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.