Phospho-4E-BP1 (Thr37/46) ELISA Kit - CD BioSciences

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Phospho-4E-BP1 (Thr37/46) ELISA Kit

Phospho-4E-BP1 (Thr37/46) ELISA Kit

SPK-00019

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Target Information
Target Name 4EBP
Gene Abbr. EIF4EBP1
Gene ID 1978
Full Name eukaryotic translation initiation factor 4E binding protein 1
Alias 4E-BP1, 4EBP1, BP-1, PHAS-I
Introduction Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity. Multiple 4E-BP1 residues are phosphorylated in vivo. While phosphorylation by FRAP/mTOR at Thr37 and Thr46 does not prevent the binding of 4E-BP1 to eIF4E, it is thought to prime 4E-BP1 for subsequent phosphorylation at Ser65 and Thr70.
Usage
Application ELISA
Reactivity
Sensitivity This kit detects endogenous levels of 4E-BP1 when phosphorylated at Thr37/46.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.