PERK Antibody - CD BioSciences

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PERK Antibody

PERK Antibody

SPA-08786

Size Price
25 µg Online Inquiry
100 µg Online Inquiry
More Options Online Inquiry
Target Information
Target Name PERK
Gene Abbr. EIF2AK3
Gene ID 9451
Full Name eukaryotic translation initiation factor 2 alpha kinase 3
Alias PEK, PERK, WRS
Introduction Protein kinase-like endoplasmic reticulum kinase (PERK) is an eIF2α kinase and transmembrane protein resident in the endoplasmic reticulum (ER) membrane that couples ER stress signals to translation inhibition. ER stress increases the activity of PERK, which then phosphorylates eIF2α to promote reduced translation. Research studies have demonstrated that PERK-deficient mice have defects in pancreatic β cells several weeks after birth, suggesting a role for PERK-mediated translational control in protecting secretory cells from ER stress. PERK activation during ER stress correlates with autophosphorylation of its cytoplasmic kinase domain. Phosphorylation of PERK at Thr980 serves as a marker for its activation status.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. 7B10
Isotype IgG2A Kappa
Immunogen EIF2AK3 (NP_002437, 665 a.a. ~ 764 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. KWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDS.
Usage
Application WB, ELISA
Dilutions Western Blot (1:100-1:2000); ELISA (1:100-1:2000)
MW(KDa) 140
Reactivity Human
Storage & Handling
Storage Buffer In 1X PBS, pH 7.4.
Preservative No Preservative
Storage Temp. Aliquot and store at -20 °C or -80 °C.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.