PDI Antibody - CD BioSciences

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PDI Antibody

PDI Antibody

SPA-08737

Size Price
25 µg Online Inquiry
100 µg Online Inquiry
More Options Online Inquiry
Target Information
Target Name PDI
Gene Abbr. P4HB
Gene ID 5034
Full Name prolyl 4-hydroxylase subunit beta
Alias CLCRP1, DSI, ERBA2L, GIT, P4Hbeta
Introduction During their synthesis, secretory proteins translocate into the endoplasmic reticulum (ER) where they are post-translationally modified and properly folded. To reach their native conformation, many secretory proteins require the formation of intra- or inter-molecular disulfide bonds. This process is called oxidative protein folding. Protein disulfide isomerase (PDI) catalyzes the formation and isomerization of these disulfide bonds. Studies on mechanisms of oxidative folding suggest that molecular oxygen oxidizes the ER-protein Ero1, which in turn oxidizes PDI through disulfide exchange. This event is then followed by PDI-catalyzed disulfide bond formation in folding proteins.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. 537331
Isotype IgG2A
Immunogen Chinese hamster ovary cell line CHO-derived recombinant human Protein Disulfide Isomerase/P4HB. Asp18-Lys505. Accession # P07237.
Usage
Application WB, IP, IF
Dilutions Western Blot (1-2 µg/mL); Immunoprecipitation (25 µg/mL); Immunofluorescence (8-25 µg/mL)
MW(KDa) 57
Reactivity Human
Specificity Detects human Protein Disulfide Isomerase/P4HB in direct ELISAs and Western Blots.
Storage & Handling
Storage Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative No Preservative
Storage Temp. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Handling Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.