PDI Antibody - CD BioSciences

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PDI Antibody

PDI Antibody

SPA-08734

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Target Information
Target Name PDI
Gene Abbr. P4HB
Gene ID 5034
Full Name prolyl 4-hydroxylase subunit beta
Alias CLCRP1, DSI, ERBA2L, GIT, P4Hbeta
Introduction During their synthesis, secretory proteins translocate into the endoplasmic reticulum (ER) where they are post-translationally modified and properly folded. To reach their native conformation, many secretory proteins require the formation of intra- or inter-molecular disulfide bonds. This process is called oxidative protein folding. Protein disulfide isomerase (PDI) catalyzes the formation and isomerization of these disulfide bonds. Studies on mechanisms of oxidative folding suggest that molecular oxygen oxidizes the ER-protein Ero1, which in turn oxidizes PDI through disulfide exchange. This event is then followed by PDI-catalyzed disulfide bond formation in folding proteins.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. 16
Isotype IgG
Immunogen This antibody was obtained from a rabbit immunized with purified, recombinant Human Protein Disulfide Isomerase/P4HB (NP_000909.2; Met 1-Lys 505).
Usage
Application WB, ELISA, IF, IP
Dilutions Western Blot (1:500-1:2000); ELISA (1:5000-1:10000); Immunofluorescence (1:20-1:100); Immunoprecipitation (1-4 µL/mg of lysate)
MW(KDa) 57
Reactivity Human
Storage & Handling
Storage Buffer 0.2 µm filtered solution in PBS.
Preservative No Preservative
Storage Temp. Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.