p95/NBS1 Antibody - CD BioSciences

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p95/NBS1 Antibody

p95/NBS1 Antibody

SPA-08567

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Target Information
Target Name p95/NBS1
Gene Abbr. NBN
Gene ID 4683
Full Name nibrin
Alias AT-V1, AT-V2, ATV, NBS, NBS1
Introduction Nijmegen breakage syndrome (NBS) is characterized by growth retardation, mental disability, immunodeficiency, defects in cell cycle checkpoints, an increased propensity for cancer, and sensitivity to ionizing radiation. Repair of radiation-induced DNA double-strand breaks is dependent on the multifunctional MRN complex containing Mre11, Rad50, and the NBS1 gene product p95/NBS1 (also called p95 or nibrin). p95/NBS1 is a protein with a forkhead-associated domain and a BRCT repeat that regulate interaction with MDC1 and are essential for proper G2/M DNA-damage checkpoint function. NBS1 is critical for homologous recombination following DNA double strand breaks. This activity requires CDK-dependent association with CtIP and subsequent phosphorylation by ATM. ATM interacts with and phosphorylates p95/NBS1 at Ser278 and Ser343 after exposure to ionizing radiation.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Immunogen Synthetic peptide corresponding to carboxy-terminal residues of human p95/NBS1.
Source/Purification Antibodies are produced by immunizing animals with a synthetic peptide corresponding to carboxy-terminal residues of human p95/NBS1. Antibodies are purified by protein A and peptide affinity chromatography.
Usage
Application WB
Dilutions Western Blot (1:1000)
MW(KDa) 95
Reactivity Human, Mouse, Rat, Monkey, Mink
Sensitivity Endogenous
Specificity It detects endogenous levels of total p95/NBS1 protein.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol.
Preservative No Preservative
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.