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OTUD5 siRNA
SPR-01228
| Size | Price |
| 1 Unit | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | OTUD5 |
| Gene Abbr. | OTUD5 |
| Gene ID | 55593 |
| Full Name | OTU deubiquitinase 5 |
| Alias | DUBA |
| Introduction | Protein ubiquitination and deubiquitination are reversible processes catalyzed by ubiquitinating enzymes and deubiquitinating enzymes, respectively. Deubiquitinating enzymes (DUBs) are categorized into five subfamilies based on catalytic domain structure: USP, OTU, MJD, UCH, and JAMM/MPN. OTUD5, also known as DUBA, belongs to the OTU family of DUBs. Phosphorylation of OTUD5 at Ser177 is required to activate its DUB activity. Research studies have shown that OTUD5 plays a pivotal role in negatively regulating innate immune responses though its ability to bind and deubiquitinate K63-linked TRAF3, thereby suppressing production of IFN-I by macrophages. There is also evidence that OTUD5 participates in the adaptive immune response by negatively regulating the production of pro-inflammatory IL-17 by Th17 cells. |
| Usage | |
|---|---|
| Application | RNA interference |
| Reactivity | |
| Storage & Handling | |
|---|---|
| Storage Buffer | The siRNA product is supplied in RNAse-free water. |
| Storage Temp. | Aliquot and store at -20 °C. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.