Nicastrin Antibody - CD BioSciences

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Nicastrin Antibody

Nicastrin Antibody

SPA-08104

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Target Information
Target Name Nicastrin
Gene Abbr. NCSTN
Gene ID 23385
Full Name nicastrin
Alias ATAG1874
Introduction Nicastrin is a transmembrane glycoprotein serving as an essential component of the γ-secretase complex. Nicastrin is physically associated with presenilin and plays an important role in the stabilization and correct localization of presenilin to the membrane-bound γ-secretase complex. Nicastrin also serves as a docking site for γ-secretase substrates such as APP and Notch, directly binding to them and properly presenting them to γ-secretase to ensure the correct cleavage process.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. D65G7
Immunogen Synthetic peptide corresponding to residues surrounding Ala700 of human nicastrin protein.
Source/Purification Antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala700 of human nicastrin protein.
Usage
Application WB, IP
Dilutions Western Blot (1:1000); Immunoprecipitation (1:50)
MW(KDa) 110, 120
Reactivity Human, Mouse, Rat, Monkey
Sensitivity Endogenous
Specificity It recognizes endogenous levels of total nicastrin protein.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide.
Preservative Less than 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.