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MYH6 Antibody
SPA-07790
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | MYH6 |
| Gene Abbr. | MYH6 |
| Gene ID | 4624 |
| Full Name | myosin heavy chain 6 |
| Alias | ASD3, CMD1EE, CMH14, MYHC, MYHCA |
| Introduction | Myosin is a highly conserved, ubiquitously expressed protein that hydrolyzes ATP, and this reaction provides the energy required for muscle contraction and that interacts with Actin to generate the force for cellular movements. It is a hexameric protein composed of four light chains and two heavy chains, each containing an actin-binding site and an ATP hydrolysis site. The heavy chains are encoded by the MYH gene family and were first isolated from a human fetal skeletal muscle and are the major determinant in the speed of contraction of skeletal muscle. Cardiac myosin exists as two isoforms in humans, a-cardiac myosins and b-cardiac myosins. These two isoforms are expressed in different amounts in the human heart. b-cardiac myosins is the predominant form during normal physiology while the a-isoform contributes for approximately 7% of the total myosin. Mutations of the MYH genes are associated with several different dilated and hypertrophic cardiomyopathies. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 940344 |
| Isotype | IgG1 |
| Immunogen | Human MYH6 peptide. P13533. |
| Usage | |
|---|---|
| Application | WB, IHC, IF |
| Dilutions | Western Blot (10 µg/mL); Immunohistochemistry (5-25 µg/mL); Immunofluorescence (8-25 µg/mL) |
| Reactivity | Human |
| Specificity | Detects human MYH6. The peptide immunogen sequence represents a region specific to MYH6 and not present in other MYH isoforms. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.