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MRGX2 Antibody
SPA-07714
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | MRGX2 |
| Gene Abbr. | MRGPRX2 |
| Gene ID | 117194 |
| Full Name | MAS related GPR family member X2 |
| Alias | MGRG3, MRGX2 |
| Introduction | MRGX2 (MAS-related GPR, member X2) is a 330 amino acid (aa) G-protein coupled 7-transmembrane protein that is selectively expressed in small-diameter sensory neurons of dorsal root ganglia. Human MRGX shares 41‑52% aa identity with three other primate MRGX proteins, but has no ortholog in rodents. Binding of ligands such as cortistatin, proadrenomedullin peptides (PAMP-12 and –20) and basic peptides (substance P, neuropeptide Y) to MRGX2 can activate Gq or Gi regulated pathways. MRGX2 is thought to influence nociception and promote adrenal gland catecholamine secretion and IgE-independent mast cell degranulation. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 477533 |
| Isotype | IgG2A |
| Immunogen | NS0 mouse myeloma cell line transfected with human MRGX2. Met1-Val330. Accession # Q96LB1. |
| Usage | |
|---|---|
| Application | FC |
| Dilutions | Flow Cytometry (0.25 µL/10^6 cells); Flow Cytometry (0.25 μg/10^6 cells) |
| Reactivity | Human |
| Specificity | Detects human MRGX2. Stains human MRGX2 transfectants but not irrelevant transfectants. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.