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MRGX2 Antibody
SPA-07713
| Size | Price |
| 0.1 mL | Online Inquiry |
| 0.025 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | MRGX2 |
| Gene Abbr. | MRGPRX2 |
| Gene ID | 117194 |
| Full Name | MAS related GPR family member X2 |
| Alias | MGRG3, MRGX2 |
| Introduction | MRGX2 (MAS-related GPR, member X2) is a 330 amino acid (aa) G-protein coupled 7-transmembrane protein that is selectively expressed in small-diameter sensory neurons of dorsal root ganglia. Human MRGX shares 41‑52% aa identity with three other primate MRGX proteins, but has no ortholog in rodents. Binding of ligands such as cortistatin, proadrenomedullin peptides (PAMP-12 and –20) and basic peptides (substance P, neuropeptide Y) to MRGX2 can activate Gq or Gi regulated pathways. MRGX2 is thought to influence nociception and promote adrenal gland catecholamine secretion and IgE-independent mast cell degranulation. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | A synthetic peptide from the 4th cytoplasmic loop of human Mas-related G-protein coupled receptor member X2 (MRGPRX2) conjugated to an immunogenic carrier protein was used as the antigen. |
| Usage | |
|---|---|
| Application | WB, IF, IHC |
| Dilutions | Western Blot (1:200-1:2000); Immunohistochemistry (1:200-1:2000) |
| Reactivity | Human, Mouse, Hamster |
| Validation | Knockdown Validated. |
| Specificity | MRGPRX2. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Whole antisera. |
| Preservative | No Preservative |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.