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MMP-14/MT1-MMP Antibody
SPA-07678
| Size | Price |
| 100 µL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | MMP-14 |
| Gene Abbr. | MMP14 |
| Gene ID | 4323 |
| Full Name | matrix metallopeptidase 14 |
| Alias | MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP |
| Introduction | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP-14 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. MT1-MMP is capable of mediating pericellular proteolysis of extracellular matrix components and is therefore thought to be an important molecular tool for cellular remodeling of the surrounding matrix. This protein also activates MMP2 protein, and this activity may be involved in tumor invasion. |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human MMP‑14/MT1‑MMP. |
| Usage | |
|---|---|
| Application | WB, FC, IHC |
| Dilutions | Western Blot (0.1 µg/mL); Flow Cytometry (2.5 µg/10^6 cells); Immunohistochemistry (5-15 µg/mL) |
| Reactivity | Human |
| Specificity | Detects human MMP‑14/MT1‑MMP in direct ELISAs and Western Blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human MMP-1, -2, -3, -7, -8, -9, -10, -12, -13, -15, and -16 is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.