MKK7 Antibody - CD BioSciences

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MKK7 Antibody

MKK7 Antibody

SPA-07638

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Target Information
Target Name MKK7
Gene Abbr. MAP2K7
Gene ID 5609
Full Name mitogen-activated protein kinase kinase 7
Alias JNKK2, MAPKK7, MEK, MEK 7, MKK7
Introduction MKK7 is a MAP kinase kinase that serves as a specific activator of the SAPK/JNK pathway. MKK7 is strongly activated by TNF-α, as well as other environmental stresses, whereas SEK1/MKK4, which activates both p38 and SAPK/JNK pathways, is not activated by TNF-α. Sequence alignment of the activation loop of the MAP kinase kinase family members indicates that Ser271 and Thr275 are potential phosphorylation sites that are crucial for the kinase acivity.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. 4D2
Isotype IgG1 Kappa
Immunogen MAP2K7 (NP_660186, 1 a.a. ~ 99 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEI.
Usage
Application WB, ELISA
Dilutions Western Blot (1:500)
MW(KDa) 48
Reactivity Human, Mouse, Rat
Specificity MAP2K7 - mitogen-activated protein kinase kinase 7.
Storage & Handling
Storage Buffer In 1X PBS, pH 7.4.
Preservative No Preservative
Storage Temp. Aliquot and store at -20 °C or -80 °C.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.