MKK6/MEK6 Antibody - CD BioSciences

service-banner

MKK6/MEK6 Antibody

MKK6/MEK6 Antibody

SPA-07624

Size Price
25 µg Online Inquiry
100 µg Online Inquiry
More Options Online Inquiry
Target Information
Target Name MKK6
Gene Abbr. MAP2K6
Gene ID 5608
Full Name mitogen-activated protein kinase kinase 6
Alias MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3
Introduction MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase. MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAPK/JNK. Phosphorylation of p38 MAP kinase dramatically stimulates its ability to phosphorylate protein substrates such as ATF-2 and Elk-1. MKK3 and MKK6 are both activated by different forms of cellular stress and inflammatory cytokines. Activation of MKK3 and MKK6 occurs through phosphorylation at Ser189 and Thr222 on MKK3 and Ser207 and Thr211 on MKK6.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen Synthetic peptide derived from the sequence of human MEK6, conjugated to KLH.
Usage
Application WB, IHC, IP
Dilutions Western Blot (1:100-1:2000); Immunohistochemistry (1:10-1:500); Immunoprecipitation (1:10-1:500)
MW(KDa) 38
Reactivity Human, Mouse, Rat, Xenopus
Specificity MKK6.
Storage & Handling
Storage Buffer Borate buffered saline, pH 8.2, containing 50% glycerol.
Preservative 0.09% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.