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mGluR7 Antibody
SPA-07558
| Size | Price |
| 0.05 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | mGluR |
| Gene Abbr. | GRM7 |
| Gene ID | 2917 |
| Full Name | glutamate metabotropic receptor 7 |
| Alias | GLUR7, GPRC1G, MGLU7, MGLUR7, NEDSHBA |
| Introduction | Metabotropic Glutamate Receptor GRM7 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. GRM7 is highly concentrated at presynaptic terminals and is thought to play an important role in the modulation of glutamatergic synaptic transmission by effecting presynaptic inhibition of glutamate release. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group III includes GRM4, GRM6, GRM7, and GRM8 receptors, which are linked to inhibition of the cyclic AMP signaling cascade. Five mRNA variants of GRM7 have been described; most of the variants are expressed in brain and retina, although there are non-neuronal variants that may have different functional properties. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Synthetic 19 amino acid peptide from N-terminal extracellular domain of human GRM7 / MGLUR7. |
| Usage | |
|---|---|
| Application | WB, IHC, IF |
| Dilutions | Western Blot (1:100-1:2000); Immunofluorescence (1:10-1:500) |
| Reactivity | Human, Bovine, Mouse, Rat, Canine, Primate, Equine, Primate-Orangutan |
| Specificity | Human mGluR7. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM8 (63%). |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS. |
| Preservative | 0.1% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.