Mer Antibody - CD BioSciences

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Mer Antibody

Mer Antibody

SPA-07481

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Target Information
Target Name Mer
Gene Abbr. MERTK
Gene ID 10461
Full Name MER proto-oncogene, tyrosine kinase
Alias MER, RP38, Tyro12, c-Eyk, c-mer
Introduction Mer tyrosine kinase belongs to a receptor tyrosine kinase family with Axl and Tyro3. This family is characterized by a common NCAM (neural adhesion molecule)-related extracellular domain and a common ligand, GAS6 (growth arrest-specific protein 6). Mer protein has an apparent molecular weight of 170-210 kDa due to different glycosylation patterns generated in different cell types. Mer can be activated by dimerization and autophosphorylation through ligand binding or homophilic cell-cell interaction mediated by its NCAM-like motif. The downstream signaling components of activated Mer include PI3 kinase, PLCγ, and MAP kinase. Family members are prone to transcriptional regulation and carry out diverse functions including the regulation of cell adhesion, migration, phagocytosis, and survival. Mer regulates macrophage activation, promotes apoptotic cell engulfment, and supports platelet aggregation and clot stability in vivo. Investigators have found that overexpression of Mer may play a cooperative role in leukemogenesis and may be an effective target for biologically based leukemia/lymphoma therapy.
Product Details
Host Rat
Clonality Monoclonal
Clone No. 108921
Isotype IgG1
Immunogen S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse Mer. Glu23-Phe498. Accession # Q60805.
Usage
Application WB, IF
Dilutions Western Blot (1 µg/mL); Immunofluorescence (8-25 µg/mL)
MW(KDa) 210
Reactivity Mouse
Specificity Detects mouse Mer in direct ELISAs and Western Blots. Does not cross-react with recombinant human Mer, recombinant mouse (rm) Axl, or rmDtk.
Storage & Handling
Storage Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative No Preservative
Storage Temp. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Handling Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

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