MEK1/2 Antibody - CD BioSciences

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MEK1/2 Antibody

MEK1/2 Antibody

SPA-07395

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Target Information
Target Name MEK1
Gene Abbr. MAP2K1
Gene ID 5604
Full Name mitogen-activated protein kinase kinase 1
Alias CFC3, MAPKK1, MEK1, MEL, MKK1
Introduction MEK1 and MEK2, also called MAPK or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation. Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221, located in the activation loop of subdomain VIII, by Raf-like molecules. MEK1/2 is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx. Constitutively active forms of MEK1/2 are sufficient for the transformation of NIH/3T3 cells or the differentiation of PC-12 cells. MEK activates p44 and p42 MAP kinase by phosphorylating both threonine and tyrosine residues at sites located within the activation loop of kinase subdomain VIII.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen A phospho specific peptide corresponding to residues surrounding S450 of human MEK1/2.
Usage
Application WB
Dilutions Western Blot (1:500-1:2000)
MW(KDa) 45
Reactivity Rat
Storage & Handling
Storage Buffer PBS with 50% glycerol, pH 7.3.
Preservative 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Avoid freeze-thaw cycles.

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