MDM2/HDM2 Antibody - CD BioSciences

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MDM2/HDM2 Antibody

MDM2/HDM2 Antibody

SPA-07321

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Target Information
Target Name MDM2
Gene Abbr. MDM2
Gene ID 4193
Full Name MDM2 proto-oncogene
Alias ACTFS, HDMX, LSKB, hdm2
Introduction MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53. Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53. Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen Synthesized peptide derived from human MDM2. The immunogen region is: C-terminal.
Usage
Application WB, ELISA, IF, IHC
Dilutions Western Blot (1:500-1:1000); ELISA (1:4000); Immunofluorescence (1:100-1:500); Immunohistochemistry (1:50-1:100)
MW(KDa) 90
Reactivity Human, Mouse
Specificity This antibody detects endogenous levels of total MDM2 protein.
Storage & Handling
Storage Buffer PBS (without Mg2+, Ca2+) (pH 7.4), 150 mM NaCl, 50% Glycerol.
Preservative 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.