MDM2/HDM2 Antibody - CD BioSciences

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MDM2/HDM2 Antibody

MDM2/HDM2 Antibody

SPA-07320

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Target Information
Target Name MDM2
Gene Abbr. MDM2
Gene ID 4193
Full Name MDM2 proto-oncogene
Alias ACTFS, HDMX, LSKB, hdm2
Introduction MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53. Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53. Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen Recombinant protein encompassing a sequence within the center region of human MDM2.
Usage
Application WB, ChIP, IHC, IP
Dilutions Western Blot (1:500-1:3000); Immunohistochemistry (1:100-1:1000); Immunoprecipitation (1:100-1:500)
MW(KDa) 90
Reactivity Human, Mouse, Porcine, Bovine, Canine, Feline, Rhesus Macaque
Storage & Handling
Storage Buffer PBS (pH 7), 20% Glycerol.
Preservative 0.025% Proclin 300
Storage Temp. Aliquot and store at -20 °C or -80 °C.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.