MDM2/HDM2 Antibody - CD BioSciences

service-banner

MDM2/HDM2 Antibody

MDM2/HDM2 Antibody

SPA-07316

Size Price
25 µg Online Inquiry
100 µg Online Inquiry
More Options Online Inquiry
Target Information
Target Name MDM2
Gene Abbr. MDM2
Gene ID 4193
Full Name MDM2 proto-oncogene
Alias ACTFS, HDMX, LSKB, hdm2
Introduction MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53. Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53. Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. 1A7
Isotype IgG1 Kappa
Immunogen MDM2 (NP_002383, 101 a.a. ~ 200 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. TMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALC.
Usage
Application WB, ELISA, IHC
Dilutions Western Blot (1:500)
MW(KDa) 90
Reactivity Human
Specificity Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse).
Storage & Handling
Storage Buffer In 1X PBS, pH 7.4.
Preservative No Preservative
Storage Temp. Aliquot and store at -20 °C or -80 °C.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.