MDM2/HDM2 Antibody - CD BioSciences

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MDM2/HDM2 Antibody

MDM2/HDM2 Antibody

SPA-07312

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100 µg Online Inquiry
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Target Information
Target Name MDM2
Gene Abbr. MDM2
Gene ID 4193
Full Name MDM2 proto-oncogene
Alias ACTFS, HDMX, LSKB, hdm2
Introduction MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53. Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53. Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen This antibody is specific for the C Terminus Region of the target protein.
Usage
Application ELISA
Dilutions ELISA (1:100-1:2000)
Reactivity Human
Specificity This product is specific for Human MDM2.
Storage & Handling
Storage Buffer 20 mM Potassium Phosphate (pH 7.0) and 0.15 M NaCl.
Preservative No Preservative
Storage Temp. Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.