MAML2 Antibody - CD BioSciences

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MAML2 Antibody

MAML2 Antibody

SPA-07168

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Target Information
Target Name MAML2
Gene Abbr. MAML2
Gene ID 84441
Full Name mastermind like transcriptional coactivator 2
Alias MAM-3, MAM2, MAM3, MLL-MAML2
Introduction Mastermind-like (MAML) family of proteins are homologs of Drosophila Mastermind. The family is composed of three members in mammals: MAML1, MAML2, and MAML3. MAML proteins form complexes with the intracellular domain of Notch (ICN) and the transcription factor CSL (RBP-Jκ) to regulate Notch target gene expression. MAML1 also interacts with myocyte enhancer factor 2C (MEF2C) to regulate myogenesis. MAML2 is frequently found to be fused with Mucoepidermoid carcinoma translocated gene 1 (MECT1, also know as WAMTP1 or TORC1) in patients with mucoepidermoid carcinomas and Warthin's tumors.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Immunogen Synthetic peptide corresponding to residues surrounding Asp800 of human MAML2.
Source/Purification Antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp800 of human MAML2. Antibodies are purified by protein A and peptide affinity chromatography.
Usage
Application WB, IP
Dilutions Western Blot (1:1000); Immunoprecipitation (1:50)
MW(KDa) 160
Reactivity Human, Mouse, Rat, Monkey
Sensitivity Endogenous
Specificity It detects endogenous levels of total MAML2 protein. It does not cross-react with MAML1 and MAML3.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol.
Preservative No Preservative
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.