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Lymphotoxin beta R/TNFRSF3 Antibody
SPA-07070
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | LTBR |
| Gene Abbr. | LTBR |
| Gene ID | 4055 |
| Full Name | lymphotoxin beta receptor |
| Alias | D12S370, LT-BETA-R, TNF-R-III, TNFCR, TNFR-RP |
| Introduction | Lymphotoxin beta receptor (LT beta R), also known as TNF RIII and TNF R-related protein (TNF Rrp) is a member of the TNF receptor superfamily, designated TNFRSF3. Human LT beta R cDNA encodes a 435 amino acid (aa) residue type I membrane protein with a putative 30 aa residue signal peptide, a 193 aa residue extracellular domain and a 171 aa residue cytoplasmic domain. The extracellular domain of LT beta R contains four cysteine-rich motifs characteristic of the TNF receptor superfamily. The cytoplasmic region of LT beta R shares little sequence similarity with other TNF receptor family members, suggesting that different signaling mechanisms may be used. LT beta R is expressed in a variety of tissues including visceral and lymphoid tissues. LT beta R is also expressed by cell lines of monocytic, epithelial, and fibroblastic origins but not by T and B lymphocytes. Human and mouse LT beta R share 76% aa sequence homology. The TNF family ligands that have been shown to bind and activate LT beta R include LIGHT (also a ligand for HVEM) and the heterotrimeric lymphotoxin LT alpha 1/ beta 2 or LT alpha 2/ beta 1. Depending on the cell type, activation of LT beta R has been shown to induce NF kappa B activation, chemokine production, growth arrest, and apoptosis. In vivo, LT beta R has been shown to play a critical role in controlling cellular immune functions and lymphoid organogenesis. Zhai, Y. et al. (1998) J. Clin. Invest. 102:1142. Rennert, P.D. et al. (1998) Immunity 9:71.. Degli-Esposti, M.A. et al. (1997) J. Immunol 158:1756. . Mackay, F. et al. (1996) J. Biol. Chem. 271:8618. . Crowe, P.D. et al. (1994) Science 264:707. |
| Product Details | |
|---|---|
| Host | Sheep |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Mouse myeloma cell line NS0 derived recombinant mouse Lymphotoxin beta Receptor. Ser28-Pro218. Accession # P50284. |
| Usage | |
|---|---|
| Application | WB, IHC |
| Dilutions | Western Blot (2 µg/mL); Immunohistochemistry (1-15 µg/mL) |
| Reactivity | Mouse |
| Specificity | Detects mouse Lymphotoxin beta R/TNFRSF3 in Western Blots. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.