LRP6 Antibody - CD BioSciences

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LRP6 Antibody

LRP6 Antibody

SPA-07043

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Target Information
Target Name LRP6
Gene Abbr. LRP6
Gene ID 4040
Full Name LDL receptor related protein 6
Alias ADCAD2, STHAG7
Introduction LRP5 and LRP6 are single-pass transmembrane proteins belonging to the low-density lipoprotein receptor (LDLR)-related protein family. Unlike other members of the LDLR family, LRP5 and LRP6 have four EGF and three LDLR repeats in the extracellular domain, and proline-rich motifs in the cytoplasmic domain. They function as co-receptors for Wnt and are required for the canonical Wnt/β-catenin signaling pathway. LRP5 and LRP6 are highly homologous and have redundant roles during development. The activity of LRP5 and LRP6 can be inhibited by the binding of some members of the Dickkopf (DKK) family of proteins. Upon stimulation with Wnt, LRP6 is phosphorylated at multiple sites including Thr1479, Ser1490, and Thr1493 by kinases such as GSK-3 and CK1. Phosphorylated LRP6 recruits axin to the membrane and presumably activates β-catenin signaling.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. C5C7
Immunogen Synthetic peptide corresponding to residues surrounding Met1409 of human LRP6.
Source/Purification Antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Met1409 of human LRP6.
Usage
Application WB, IP
Dilutions Western Blot (1:1000); Immunoprecipitation (1:50)
MW(KDa) 180, 210
Reactivity Human, Rat
Sensitivity Endogenous
Specificity It detects endogenous levels of total LRP6 protein.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide.
Preservative Less than 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.